RapamycinFungusV1, Main, Exploration, bibRecord, 001504

Mutation of a phosphorylatable residue in Put3p affects the magnitude of rapamycin-induced PUT1 activation in a Gat1p-dependent manner.

Identifieur interne : 001504 ( Main/Exploration ); précédent : 001503; suivant : 001505

Mutation of a phosphorylatable residue in Put3p affects the magnitude of rapamycin-induced PUT1 activation in a Gat1p-dependent manner.

Auteurs : Michael K. Leverentz [Royaume-Uni] ; Robert N. Campbell ; Yvonne Connolly ; Anthony D. Whetton ; Richard J. Reece

Source :

The Journal of biological chemistry [ 0021-9258 ] ; 2009.

RBID : pubmed:19574222

Descripteurs français

English descriptors

KwdEn :
- Antifungal Agents (pharmacology), GATA Transcription Factors (genetics), GATA Transcription Factors (metabolism), Gene Expression Regulation, Fungal (drug effects), Gene Expression Regulation, Fungal (genetics), Mutation (MeSH), Phosphorylation (drug effects), Phosphorylation (genetics), Proline (genetics), Proline (metabolism), Proline Oxidase (biosynthesis), Proline Oxidase (genetics), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Sirolimus (pharmacology), Transcription Factors (genetics), Transcription Factors (metabolism), Transcription, Genetic (drug effects), Transcription, Genetic (genetics).
MESH :
- chemical , biosynthesis : Proline Oxidase.
- chemical , genetics : GATA Transcription Factors, Proline, Proline Oxidase, Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemical , metabolism : GATA Transcription Factors, Proline, Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemical , pharmacology : Antifungal Agents, Sirolimus.
- drug effects : Gene Expression Regulation, Fungal, Phosphorylation, Transcription, Genetic.
- genetics : Gene Expression Regulation, Fungal, Phosphorylation, Saccharomyces cerevisiae, Transcription, Genetic.
- metabolism : Saccharomyces cerevisiae.
- Mutation.

Abstract

Saccharomyces cerevisiae can utilize high quality (e.g. glutamine and ammonia) as well as low quality (e.g. gamma-amino butyric acid and proline) nitrogen sources. The transcriptional activator Put3p allows yeast cells to utilize proline as a nitrogen source through expression of the PUT1 and PUT2 genes. Put3p activates high level transcription of these genes by binding proline directly. However, Put3p also responds to other lower quality nitrogen sources. As nitrogen quality decreases, Put3p exhibits an increase in phosphorylation concurrent with an increase in PUT gene expression. The proline-independent activation of the PUT genes requires both Put3p and the positively acting GATA factors, Gln3p and Gat1p. Conversely, the phosphorylation of Put3p is not dependent on GATA factor activity. Here, we find that the mutation of Put3p at amino acid Tyr-788 modulates the proline-independent activation of PUT1 through Gat1p. The phosphorylation of Put3p appears to influence the association of Gat1p, but not Gln3p, to the PUT1 promoter. Combined, our findings suggest that this may represent a mechanism through which yeast cells rapidly adapt to use proline as a nitrogen source under nitrogen limiting conditions.

DOI: 10.1074/jbc.M109.030361
PubMed: 19574222
PubMed Central: PMC2782005

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 001496
to stream Main, to step Curation: 001496

Le document en format XML

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<term>Gene Expression Regulation, Fungal (drug effects)</term>
<term>Gene Expression Regulation, Fungal (genetics)</term>
<term>Mutation (MeSH)</term>
<term>Phosphorylation (drug effects)</term>
<term>Phosphorylation (genetics)</term>
<term>Proline (genetics)</term>
<term>Proline (metabolism)</term>
<term>Proline Oxidase (biosynthesis)</term>
<term>Proline Oxidase (genetics)</term>
<term>Saccharomyces cerevisiae (genetics)</term>
<term>Saccharomyces cerevisiae (metabolism)</term>
<term>Saccharomyces cerevisiae Proteins (genetics)</term>
<term>Saccharomyces cerevisiae Proteins (metabolism)</term>
<term>Sirolimus (pharmacology)</term>
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<term>Transcription Factors (metabolism)</term>
<term>Transcription, Genetic (drug effects)</term>
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<term>Facteurs de transcription (génétique)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Facteurs de transcription GATA (génétique)</term>
<term>Facteurs de transcription GATA (métabolisme)</term>
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<term>Phosphorylation (génétique)</term>
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<term>Proline (métabolisme)</term>
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<term>Proline dehydrogenase (génétique)</term>
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<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
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<term>Transcription génétique (effets des médicaments et des substances chimiques)</term>
<term>Transcription génétique (génétique)</term>
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<front><div type="abstract" xml:lang="en">Saccharomyces cerevisiae can utilize high quality (e.g. glutamine and ammonia) as well as low quality (e.g. gamma-amino butyric acid and proline) nitrogen sources. The transcriptional activator Put3p allows yeast cells to utilize proline as a nitrogen source through expression of the PUT1 and PUT2 genes. Put3p activates high level transcription of these genes by binding proline directly. However, Put3p also responds to other lower quality nitrogen sources. As nitrogen quality decreases, Put3p exhibits an increase in phosphorylation concurrent with an increase in PUT gene expression. The proline-independent activation of the PUT genes requires both Put3p and the positively acting GATA factors, Gln3p and Gat1p. Conversely, the phosphorylation of Put3p is not dependent on GATA factor activity. Here, we find that the mutation of Put3p at amino acid Tyr-788 modulates the proline-independent activation of PUT1 through Gat1p. The phosphorylation of Put3p appears to influence the association of Gat1p, but not Gln3p, to the PUT1 promoter. Combined, our findings suggest that this may represent a mechanism through which yeast cells rapidly adapt to use proline as a nitrogen source under nitrogen limiting conditions.</div>
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<Abstract><AbstractText>Saccharomyces cerevisiae can utilize high quality (e.g. glutamine and ammonia) as well as low quality (e.g. gamma-amino butyric acid and proline) nitrogen sources. The transcriptional activator Put3p allows yeast cells to utilize proline as a nitrogen source through expression of the PUT1 and PUT2 genes. Put3p activates high level transcription of these genes by binding proline directly. However, Put3p also responds to other lower quality nitrogen sources. As nitrogen quality decreases, Put3p exhibits an increase in phosphorylation concurrent with an increase in PUT gene expression. The proline-independent activation of the PUT genes requires both Put3p and the positively acting GATA factors, Gln3p and Gat1p. Conversely, the phosphorylation of Put3p is not dependent on GATA factor activity. Here, we find that the mutation of Put3p at amino acid Tyr-788 modulates the proline-independent activation of PUT1 through Gat1p. The phosphorylation of Put3p appears to influence the association of Gat1p, but not Gln3p, to the PUT1 promoter. Combined, our findings suggest that this may represent a mechanism through which yeast cells rapidly adapt to use proline as a nitrogen source under nitrogen limiting conditions.</AbstractText>
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	Serveur d'exploration sur la rapamycine et les champignons
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Mutation of a phosphorylatable residue in Put3p affects the magnitude of rapamycin-induced PUT1 activation in a Gat1p-dependent manner.

Mutation of a phosphorylatable residue in Put3p affects the magnitude of rapamycin-induced PUT1 activation in a Gat1p-dependent manner.

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